4-Methoxy-2-(methylthio)pyrimidine-5-carboxylic acid

Name: 4-Methoxy-2-(methylthio)pyrimidine-5-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 84332-06-9
Cat. No. CS-0112787
Purity≥95%
MDL No.MFCD02671593

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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4-Methoxy-2-(methylthio)pyrimidine-5-carboxylic acid|CS-0112787

Structure of 84332-06-9

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General Information

CAS No. 84332-06-9
Cat. No. CS-0112787
Purity ≥95%
MDL No. MFCD02671593
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈N₂O₃S
Molecular Weight 200.22
Synonym(s) 4-Methoxy-2-(methylthio)-5-pyrimidinecarboxylic acid
SMILES O=C(C1=CN=C(SC)N=C1OC)O

Description

4-Methoxy-2-(methylthio)pyrimidine-5-carboxylic acid features a pyrimidine core functionalized with methoxy, methylthio, and carboxylic acid groups, enabling integration into bioactive scaffolds. The electron-rich heterocycle supports conjugation and metal coordination, while the carboxylic acid facilitates derivatization. This compound serves as a key intermediate in medicinal chemistry and agrochemical synthesis.

Application

4-Methoxy-2-(methylthio)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrimidine-based scaffolds through established coupling and functional group interconversions. Its carboxylic acid functionality facilitates amide bond formation, while the methoxy and methylthio groups provide orthogonal handles for selective derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, supporting efficient integration into multi-step synthetic sequences for API development.

Synthesis

Route1
- 67-56-1
- 5909-24-0
- ~%
- In-stock
  
  84332-06-9
References
- Huang, Hui; Hutta, Daniel A.; Rinker, James M.; Hu, Aping; Parsons, William H.; Schubert, Carsten; Desjarlais, Renee L.; Crysler, Carl S.; Chaikin, Margery A.; Donatelli, Robert R.; Chen, Yanmin; Cheng, Deping; Zhou, Zhao; Yurkow, Edward; Manthey, Carl L.; Player, Mark R. Journal of Medicinal Chemistry, 2009 , vol. 52, # 4 p. 1081 - 1099

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302+H312+H332
Precautionary Statements : P235-P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P405-P501

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Computational Chemistry Data

TPSA 72.31
LogP 0.9053
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

84332-06-9 sigma84332-06-9 manufacturer84332-06-9 price84332-06-9 structure84332-06-9 SDSbuy 84332-06-984332-06-9 supplier84332-06-9 uses84332-06-9 molecular weightprice of 84332-06-984332-06-9 chemical name formula of 84332-06-9

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4-Methoxy-2-(methylthio)pyrimidine-5-carboxylic acid

CAS No. 84332-06-9

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