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CS-W001157 4
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2-Chloro-5-fluorobenzaldehyde

  • CAS No. 84194-30-9

  • Cat. No. CS-W003102
  • Purity≥97%
  • MDL No.MFCD03788511

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-fluorobenzaldehyde|CS-W003102

Structure of 84194-30-9

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General Information

  • CAS No. 84194-30-9
  • Cat. No. CS-W003102
  • Purity ≥97%
  • MDL No. MFCD03788511
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO
  • Molecular Weight 158.56
  • Synonym(s) 2-Chloro-5-Fluoro Benzaldehyde; 2-Chloro-5-fluorobenzaldehyde
  • SMILES ClC1=CC=C(F)C=C1C=O

Description

2-Chloro-5-fluorobenzaldehyde features a fluorinated aromatic ring with complementary electron-withdrawing chlorine and fluorine substituents, enhancing electrophilicity at the aldehyde group. This combination enables selective coupling reactions in synthetic routes to pharmaceutical intermediates and functionalized heterocycles under standard conditions.

Application

2-Chloro-5-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles and biaryl scaffolds. Its orthogonal halogenation pattern facilitates selective cross-coupling reactions, while the aldehyde functionality allows for facile derivatization via reductive amination, condensation, or cyanohydrin formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 48, # 4 p. 526 - 532
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 19, # 6 p. 1930 - 1949
  • Route3

    References

    • Bioorganic and Medicinal Chemistry, , vol. 19, # 6 p. 1930 - 1949

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2916
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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