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CS-W001157 4
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7-Bromoquinolin-6-ol

  • CAS No. 84174-71-0

  • Cat. No. CS-0188447
  • Purity≥98%
  • MDL No.MFCD18413587

*For research and further manufacturing use only, not for direct human use.

7-Bromoquinolin-6-ol|CS-0188447

Structure of 84174-71-0

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General Information

  • CAS No. 84174-71-0
  • Cat. No. CS-0188447
  • Purity ≥98%
  • MDL No. MFCD18413587
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrNO
  • Molecular Weight 224.06
  • Synonym(s) 7-bromo-quinolin-6-ol
  • SMILES C1=CC2=C(C=C(C(=C2)O)Br)N=C1

Description

7-Bromoquinolin-6-ol features a brominated quinoline scaffold with a phenolic hydroxyl group, enabling direct functionalization in cross-coupling and derivatization workflows. The electron-deficient aromatic system enhances reactivity in palladium-catalyzed transformations, while the hydroxyl moiety offers anchoring points for further conjugation. This bench-stable compound serves as a key intermediate in medicinal chemistry and materials synthesis.

Application

7-Bromoquinolin-6-ol serves as a versatile building block in medicinal chemistry and materials science, enabling direct functionalization at the C6 hydroxyl and C7 bromine sites. Its dual reactivity facilitates Suzuki-Miyaura coupling, nucleophilic substitution, and transition-metal-catalyzed cross-coupling reactions. The compound exhibits good bench stability and is readily purified by crystallization or flash chromatography, making it well-suited for scalable synthesis of quinoline-based pharmaceutical intermediates and heterocyclic scaffolds.

Safety Information

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.7029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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