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CS-W001157 4
Total: USD 88.00

Methoxyamiodarone impurity 1

  • CAS No. 83790-87-8

  • Cat. No. CS-M1368
  • Purity≥98%
  • MDL No.MFCD11215603

*For research and further manufacturing use only, not for direct human use.

Methoxyamiodarone impurity 1|CS-M1368

Structure of 83790-87-8

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General Information

  • CAS No. 83790-87-8
  • Cat. No. CS-M1368
  • Purity ≥98%
  • MDL No. MFCD11215603
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₀O₃
  • Molecular Weight 308.37
  • Synonym(s) None
  • SMILES O=C(C(C=C1)=CC=C1OC)C2=C(CCCC)OC3=CC=CC=C23

Description

This ketone integrates a 2-butylbenzofuran-3-yl moiety with a 4-methoxyphenyl group, delivering enhanced solubility and stability under standard conditions. The electron-donating methoxy substituent modulates reactivity, while the extended aromatic system supports conjugation for applications in organic synthesis and pharmaceutical intermediates.

Application

(2-Butylbenzofuran-3-yl)(4-methoxyphenyl)methanone serves as a versatile building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds. Its benzofuran core provides structural rigidity and metabolic stability, while the aryl ketone functionality facilitates diverse transformations including nucleophilic additions, Grignard reactions, and reductive amination. The 4-methoxyphenyl group enhances solubility and modulates electronic properties, supporting efficient downstream derivatization. This compound exhibits excellent bench stability and is amenable to standard purification techniques, making it well-suited for high-throughput synthesis and process development.

Synthesis

  • Route1
    • null|null
      75-44-5
    • 2-Butylbenzofuran|CS-0206015
      4265-27-4
    • null|null
      75-34-3
    • ~78%
    • In-stock
      Methoxyamiodarone impurity 1|CS-M1368
      83790-87-8

    References

    • Sanofi Patent: US5266711 A1, 1993 ;
  • Route2
    • 2-Butylbenzofuran|CS-0206015
      4265-27-4
    • null|null
      100-07-2
    • ~65%
    • In-stock
      Methoxyamiodarone impurity 1|CS-M1368
      83790-87-8

    References

    • J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi Patent: WO2012/48058 A2, 2012 ; Location in patent: Page/Page column 42-43 ; WO 2012/048058 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS09
Signal Word : Warning
UN#: 3082
Class : 9
Packing Group : Ⅲ
Hazard Statements : H400-H410
Precautionary Statements : P273-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.44
  • LogP   5.015
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   6

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