Lot numbers can be found on the outside label of a product:
Please log in for operation!
*For research and further manufacturing use only, not for direct human use.
Structure of 83730-53-4
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Irreversibly inhibiting γ-glutamylcysteine synthetase with first-order kinetics (t₁/₂ ≈ 11 sec), L-Buthionine-sulfoximine (CAS 83730-53-4) depletes intracellular glutathione, selectively sensitizing melanoma, breast, and ovarian cancer cells to chemothera
L-Buthionine-sulfoximine (CAS 83730-53-4) induces experimental glutathione deficiency by irreversibly inhibiting gamma-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione synthesis. This disruption reveals glutathione’s critical role in redox balance. Researchers leverage this effect to dissect oxidative stress pathways, validate antioxidant mechanisms, and study apoptosis regulation in cancer cell lines.
|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P280-P302+P352
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Lot numbers can be found on the outside label of a product: