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CS-W001157 4
Total: USD 88.00

2,6-Dichlorobenzaldehyde

  • CAS No. 83-38-5

  • Cat. No. CS-W007684
  • Purity≥96%
  • MDL No.MFCD00003307

*For research and further manufacturing use only, not for direct human use.

2,6-Dichlorobenzaldehyde|CS-W007684

Structure of 83-38-5

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General Information

  • CAS No. 83-38-5
  • Cat. No. CS-W007684
  • Purity ≥96%
  • MDL No. MFCD00003307
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄Cl₂O
  • Molecular Weight 175.01
  • Synonym(s) o,o'-dichlorobenzaldehyde; 2,6-Dichlorobenzaldehyde
  • SMILES C1=CC=C(C(=C1Cl)C=O)Cl

Description

2,6-Dichlorobenzaldehyde features two chlorine atoms positioned at the 2- and 6-positions relative to the aldehyde group, conferring enhanced electrophilicity and steric protection. This electron-deficient aromatic aldehyde serves as a key building block in pharmaceutical synthesis and heterocyclic chemistry, offering improved stability under standard bench conditions.

Application

2,6-Dichlorobenzaldehyde serves as a versatile building block in synthetic organic chemistry, enabling the construction of heterocyclic scaffolds and functionalized aromatics. Its ortho-chlorine substituents enhance electrophilicity at the carbonyl carbon while providing orthogonal reactivity for downstream modifications. The compound exhibits excellent bench stability, facilitates clean purification, and demonstrates broad compatibility in coupling reactions, nucleophilic additions, and imine-based transformations.

Synthesis

  • Route1

    References

    • Organic Preparations and Procedures International, , vol. 26, # 5 p. 583 - 588
  • Route2
    • 2,6-Dichlorophenylacetic acid Guanfacine Hydrochloride  Impurity|CS-0229412
      6575-24-2
    • ~87%
    • In-stock
      2,6-Dichlorobenzaldehyde|CS-W007684
      83-38-5

    References

    • Montazerozohori; Nasr-Esfahani; Joohari; Akhlaghi; Dehghani Asian Journal of Chemistry, 2011 , vol. 23, # 3 p. 1081 - 1084
  • Route3

    References

    • Zhu, Chenjie; Zhang, Zhi; Ding, Weiwei; Xie, Jingjing; Chen, Yong; Wu, Jinglan; Chen, Xiaochun; Ying, Hanjie Green Chemistry, 2014 , vol. 16, # 3 p. 1131 - 1138

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8059
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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