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CS-W001157 4
Total: USD 88.00

Aceclidine

  • CAS No. 827-61-2

  • Cat. No. CS-B0278
  • Purity≥98%
  • MDL No.MFCD00468105

*For research and further manufacturing use only, not for direct human use.

Aceclidine|CS-B0278

Structure of 827-61-2

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General Information

  • CAS No. 827-61-2
  • Cat. No. CS-B0278
  • Purity ≥98%
  • MDL No. MFCD00468105
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₅NO₂
  • Molecular Weight 169.22
  • Synonym(s) Quinuclidin-3-yl acetate
  • SMILES CC(OC1C[N@@]2CC[C@H]1CC2)=O

Description

Aceclidine is a potent muscarinic receptor agonist featuring a quinuclidine core that delivers robust and sustained activation of M1/M3 subtypes. This bench-stable compound exhibits favorable solubility in aqueous media and maintains activity under standard handling conditions, enabling reliable use in receptor pharmacology studies and functional assays.

Application

Aceclidine serves as a well-established cholinergic agonist used in the synthesis of muscarinic receptor-targeted compounds. Its pyrrolidinyl quinuclidine core enables selective interaction with M1–M4 subtypes, facilitating studies in neuropharmacology and ocular therapeutics. The molecule exhibits favorable bench stability and functional group tolerance, enabling straightforward derivatization in standard medicinal chemistry workflows.

Synthesis

  • Route1
    • null|null
      108-24-7
    • null|null
      1619-34-7
    • ~90%
    • In-stock
      Aceclidine|CS-B0278
      827-61-2

    References

    • Langlois; Meyer; Soulier Synthetic Communications, 1992 , vol. 22, # 13 p. 1895 - 1911
  • Route2
    • null|null
      1619-34-7
    • ~60%
    • In-stock
      Aceclidine|CS-B0278
      827-61-2

    References

    • Bracco International B.V. Patent: US5387409 A1, 1995 ;
  • Route3
    • null|null
      1193-65-3
    • ~%
    • In-stock
      Aceclidine|CS-B0278
      827-61-2

    References

    • Helvetica Chimica Acta, , vol. 40, p. 2170,2176

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   0.6437
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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