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Structure of 825-83-2
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4-(Trifluoromethyl)benzenethiol features a trifluoromethyl group flanking a reactive thiol moiety, enabling robust conjugation in bioorthogonal chemistry. This electron-deficient arylthiol exhibits enhanced stability and solubility in organic media, facilitating efficient coupling reactions under mild conditions.
4-(Trifluoromethyl)benzenethiol serves as a valuable building block for sulfur-containing aromatic systems, enabling efficient construction of biaryls and heterocycles via cross-coupling reactions. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it useful in medicinal chemistry lead optimization. The thiol functionality facilitates orthogonal conjugation and metal coordination, while the compound exhibits good bench stability and ease of purification in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: