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CS-W001157 4
Total: USD 88.00

2-Phenyl-1,3,4-oxadiazole

  • CAS No. 825-56-9

  • Cat. No. CS-0119950
  • Purity≥98%
  • MDL No.MFCD00491613

*For research and further manufacturing use only, not for direct human use.

2-Phenyl-1,3,4-oxadiazole|CS-0119950

Structure of 825-56-9

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General Information

  • CAS No. 825-56-9
  • Cat. No. CS-0119950
  • Purity ≥98%
  • MDL No. MFCD00491613
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 1,3,4-OXADIAZOLE,2-PHENYL
  • SMILES C1(C2=CC=CC=C2)=NN=CO1

Description

2-Phenyl-1,3,4-oxadiazole is a stable heterocyclic compound featuring a fused oxadiazole ring with a phenyl substituent. This structure imparts enhanced rigidity and electron-deficient character, making it valuable in pharmaceutical scaffolds and materials chemistry. The molecule exhibits favorable solubility in organic solvents and resistance to degradation under standard bench conditions.

Application

2-Phenyl-1,3,4-oxadiazole serves as a stable, bench-ready heterocyclic building block with well-documented utility in medicinal chemistry and materials science. Its aromatic substitution pattern enables straightforward functionalization and incorporation into bioactive scaffolds. The oxadiazole ring exhibits excellent thermal and chemical stability, facilitating purification and compatibility with common reaction conditions. Functions as a versatile pharmacophore and is widely employed in the synthesis of kinase inhibitors, antitumor agents, and fluorescent probes.

Synthesis

  • Route1
    • null|null
      73789-56-7
    • In-stock
      Benzoic acid|CS-0008257
      65-85-0
    • ~94%
    • In-stock
      2-Phenyl-1,3,4-oxadiazole|CS-0119950
      825-56-9

    References

    • Ultrasonics Sonochemistry, , vol. 21, # 1 p. 262 - 267
  • Route2
    • Benzohydrazide Azelastine Impurity|CS-0229712
      613-94-5
    • null|null
      149-73-5
    • ~90%
    • In-stock
      2-Phenyl-1,3,4-oxadiazole|CS-0119950
      825-56-9

    References

    • Monatshefte fur Chemie, , vol. 138, # 12 p. 1253 - 1255
  • Route3
    • Benzohydrazide Azelastine Impurity|CS-0229712
      613-94-5
    • null|null
      122-51-0
    • ~98%
    • In-stock
      2-Phenyl-1,3,4-oxadiazole|CS-0119950
      825-56-9

    References

    • Tetrahedron, , vol. 68, # 1 p. 300 - 305

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.92
  • LogP   1.7366
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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