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CS-W001157 4
Total: USD 88.00

2,3-Difluoro-6-nitrophenol

  • CAS No. 82419-26-9

  • Cat. No. CS-W001649
  • Purity≥98%
  • MDL No.MFCD00042255

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-6-nitrophenol|CS-W001649

Structure of 82419-26-9

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General Information

  • CAS No. 82419-26-9
  • Cat. No. CS-W001649
  • Purity ≥98%
  • MDL No. MFCD00042255
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₃
  • Molecular Weight 175.09
  • Synonym(s) Benzamide, 4-fluoro-
  • SMILES OC1=C([N+]([O-])=O)C=CC(F)=C1F

Description

2,3-Difluoro-6-nitrophenol features a fluorinated aromatic ring paired with a nitro group at the para position, delivering enhanced electron deficiency and reactivity. This configuration supports efficient coupling in cross-coupling reactions and facilitates incorporation into advanced pharmaceutical intermediates and functional materials under standard conditions.

Application

2,3-Difluoro-6-nitrophenol serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling the construction of fluorinated heterocycles and functionalized aromatic scaffolds. Its ortho-fluoro substituents facilitate nucleophilic aromatic substitution, while the nitro group provides a versatile handle for reduction and subsequent coupling reactions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthetic workflows.

Synthesis

  • Route1

    References

    • Hoechst Aktiengesellschaft Patent: US5292967 A1, 1994 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.37
  • LogP   1.5786
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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