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CS-W001157 4
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4-Methyl-1H-pyrrolo[2,3-b]pyridine

  • CAS No. 824-24-8

  • Cat. No. CS-0004137
  • Purity≥97%
  • MDL No.MFCD00956196

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1H-pyrrolo[2,3-b]pyridine|CS-0004137

Structure of 824-24-8

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General Information

  • CAS No. 824-24-8
  • Cat. No. CS-0004137
  • Purity ≥97%
  • MDL No. MFCD00956196
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight 132.16
  • Synonym(s) 4-METHYL-7-AZAINDOLE
  • SMILES CC1=C2C(NC=C2)=NC=C1

Description

4-Methyl-1H-pyrrolo[2,3-b]pyridine is a heterocyclic scaffold featuring a fused pyrrole-pyridine core with a methyl substituent at the 4-position. This electron-rich system offers enhanced stability and solubility in organic media, enabling efficient integration into pharmaceutical intermediates and functional materials. The methyl group improves metabolic resistance while maintaining favorable reactivity for C–H functionalization and transition-metal-catalyzed coupling processes.

Application

4-Methyl-1H-pyrrolo[2,3-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive scaffolds. Its electron-rich pyrrolopyridine core exhibits favorable reactivity in cross-coupling and electrophilic substitution reactions, with the methyl group providing a handle for further functionalization. The compound demonstrates good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.87132
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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