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CS-W001157 4
Total: USD 88.00

Ethyl 2-(benzofuran-3-yl)acetate

  • CAS No. 82156-58-9

  • Cat. No. CS-0151594
  • Molecule weight204.22
  • Purity≥98%
  • MDL No.MFCD08060514

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(benzofuran-3-yl)acetate|CS-0151594

Structure of 82156-58-9

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General Information

  • CAS No. 82156-58-9
  • Cat. No. CS-0151594
  • Purity ≥98%
  • MDL No. MFCD08060514
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₂O₃
  • Molecular Weight 204.22
  • Synonym(s) Ethyl 1-benzofuran-3-ylacetate
  • SMILES CCOC(=O)CC1=COC2=CC=CC=C12

Description

Ethyl 2-(benzofuran-3-yl)acetate integrates a benzofuran core with an acrylate-like ester handle, enabling direct coupling in cross-coupling and cyclization cascades. This bench-stable, moisture-tolerant reagent features high functional group compatibility and delivers efficient access to fused heterocyclic scaffolds under standard conditions.

Application

Ethyl 2-(benzofuran-3-yl)acetate serves as a versatile building block for benzofuran-based pharmaceutical intermediates, enabling efficient construction of bioactive scaffolds. Its ester functionality facilitates subsequent transformations including hydrolysis, reduction, and coupling reactions. The molecule exhibits good bench stability and is compatible with standard reaction conditions, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Asselin, Magda; Grosu, George Theodore; Evrard, Deborah A.; Mewshaw, Richard Eric; Meagher, Kristin Patent: US2009/54454 A1, 2009 ; Location in patent: Page/Page column 21 ; US 20090054454 A1
  • Route2
    • null|null
      881015-10-7
    • ~86%
    • In-stock
      Ethyl 2-(benzofuran-3-yl)acetate|CS-0151594
      82156-58-9

    References

    • Albaneze-Walker; Rossen; Reamer; Volante; Reider Tetrahedron Letters, 1999 , vol. 40, # 27 p. 4917 - 4920
  • Route3
    • In-stock
      3-Coumaranone|CS-W001165
      7169-34-8
    • 2-(Triphenylphosphoranylidene)acetic acid|CS-0372614
      15677-02-8
    • ~99%
    • In-stock
      Ethyl 2-(benzofuran-3-yl)acetate|CS-0151594
      82156-58-9

    References

    • Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Gu, Yansong Patent: US2005/4162 A1, 2005 ; Location in patent: Page/Page column 11 ; US 20050004162 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.44
  • LogP   2.5384
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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