Lot numbers can be found on the outside label of a product:
3-Bromo-1-methyl-1,2-dihydropyridin-2-one
-
CAS No. 81971-38-2
- Cat. No. CS-0051492
- Purity≥96%
- MDL No.MFCD11226865
*For research and further manufacturing use only, not for direct human use.
Structure of 81971-38-2
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 81971-38-2
- Cat. No. CS-0051492
- Purity ≥96%
- MDL No. MFCD11226865
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₆BrNO
- Molecular Weight 188.02
- Synonym(s) 3-Bromo-1-methylpyridin-2(1H)-one
- SMILES CN1C=CC=C(Br)C1=O
Description
3-Bromo-1-methyl-1,2-dihydropyridin-2-one is a bench-stable, electron-deficient heterocycle featuring a bromine substituent at the 3-position and a methyl group at nitrogen. This structure enables direct functionalization in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive pyridine derivatives.
Application
3-Bromo-1-methyl-1,2-dihydropyridin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridones via palladium-catalyzed cross-coupling reactions. The bromine atom facilitates reliable C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the enaminone functionality supports further functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for modular synthesis of bioactive heterocycles and API intermediates.
Synthesis
-
Route1
-
In-stock
13466-43-8 -
74-88-4 - ~99%
-
In-stock
81971-38-2
References
-
Becknell, Nadine C.; Lyons, Jacquelyn A.; Aimone, Lisa D.; Gruner, John A.; Mathiasen, Joanne R.; Raddatz, Rita; Hudkins, Robert L. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7076 - 7080
-
-
Route2
-
In-stock
13466-43-8
-
77-78-1
- ~84%
-
In-stock
81971-38-2
References
-
Tee, Oswald S.; Paventi, Martino Journal of the American Chemical Society, 1982 , vol. 104, # 15 p. 4142 - 4146
-
-
Route3
-
142-08-5 - ~%
-
In-stock
81971-38-2
References
-
Elan Pharmaceuticals, Inc. Patent: US6465513 B1, 2002 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H320-H335
|
|
|
Precautionary Statements : P261-P280-P302+P352
|
|
Quality Control
Computational Chemistry Data
- TPSA 22
- LogP 1.1478
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 81971-38-2 sigma81971-38-2 manufacturer81971-38-2 price81971-38-2 structure81971-38-2 SDSbuy 81971-38-281971-38-2 supplier81971-38-2 uses81971-38-2 molecular weightprice of 81971-38-281971-38-2 chemical name formula of 81971-38-2