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CS-W001157 4
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3-Bromo-1-methyl-1,2-dihydropyridin-2-one

  • CAS No. 81971-38-2

  • Cat. No. CS-0051492
  • Purity≥96%
  • MDL No.MFCD11226865
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1-methyl-1,2-dihydropyridin-2-one|CS-0051492

Structure of 81971-38-2

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Description

3-Bromo-1-methyl-1,2-dihydropyridin-2-one is a bench-stable, electron-deficient heterocycle featuring a bromine substituent at the 3-position and a methyl group at nitrogen. This structure enables direct functionalization in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive pyridine derivatives.

Application

3-Bromo-1-methyl-1,2-dihydropyridin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridones via palladium-catalyzed cross-coupling reactions. The bromine atom facilitates reliable C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the enaminone functionality supports further functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for modular synthesis of bioactive heterocycles and API intermediates.

General Information

  • CAS No. 81971-38-2
  • Cat. No. CS-0051492
  • Purity ≥96%
  • MDL No. MFCD11226865
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO
  • Molecular Weight 188.02
  • Synonym(s) 3-Bromo-1-methylpyridin-2(1H)-one
  • SMILES CN1C=CC=C(Br)C1=O

Computational Chemistry Data

  • TPSA   22
  • LogP   1.1478
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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