Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

  • CAS No. 819057-45-9

  • Cat. No. CS-W005873
  • Purity≥95%
  • MDL No.MFCD09951877

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline|CS-W005873

Structure of 819057-45-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 819057-45-9
  • Cat. No. CS-W005873
  • Purity ≥95%
  • MDL No. MFCD09951877
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇BFNO₂
  • Molecular Weight 237.08
  • Synonym(s) Benzenamine,3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • SMILES NC1=CC=C(B2OC(C)(C)C(C)(C)O2)C(F)=C1

Description

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline features a boronate ester group that enables efficient Suzuki-Miyaura coupling under mild conditions. The para-fluorinated aryl scaffold imparts enhanced metabolic stability and electron-withdrawing character, facilitating precise functionalization in complex molecule synthesis. This bench-stable reagent integrates seamlessly into late-stage derivatization workflows.

Application

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The ortho-fluorinated aryl group enables directed functionalization, while the stable boronate ester facilitates efficient coupling with aryl halides and pseudohalides. Its bench-stable nature and excellent functional group tolerance make it ideal for constructing complex biaryl scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Qiu, Di; Wang, Shuai; Tang, Shengbo; Meng, He; Jin, Liang; Mo, Fanyang; Zhang, Yan; Wang, Jianbo Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 1979 - 1988
  • Route2

    References

    • Birch, Alan M.; Groombridge, Sam; Law, Robert; Leach, Andrew G.; Mee, Christine D.; Schramm, Carolin Journal of Medicinal Chemistry, 2012 , vol. 55, # 8 p. 3923 - 3933
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 79, # 5 p. 1979 - 1988

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.7071
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 819057-45-9 sigma819057-45-9 manufacturer819057-45-9 price819057-45-9 structure819057-45-9 SDSbuy 819057-45-9819057-45-9 supplier819057-45-9 uses819057-45-9 molecular weightprice of 819057-45-9819057-45-9 chemical name formula of 819057-45-9
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label