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CS-W001157 4
Total: USD 88.00

2-(2-Bromo-5-chlorophenyl)acetic acid

  • CAS No. 81682-38-4

  • Cat. No. CS-W005252
  • Purity≥98%
  • MDL No.MFCD00153890

*For research and further manufacturing use only, not for direct human use.

2-(2-Bromo-5-chlorophenyl)acetic acid|CS-W005252

Structure of 81682-38-4

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General Information

  • CAS No. 81682-38-4
  • Cat. No. CS-W005252
  • Purity ≥98%
  • MDL No. MFCD00153890
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrClO₂
  • Molecular Weight 249.49
  • Synonym(s) 2-Bromo-5-chlorophenylacetic acid
  • SMILES O=C(O)CC1=CC(Cl)=CC=C1Br

Description

2-(2-Bromo-5-chlorophenyl)acetic acid features a brominated and chlorinated aromatic core that imparts enhanced electron-withdrawing character, facilitating downstream functionalization. This bench-stable carboxylic acid derivative integrates readily into synthetic sequences requiring halogenated aryl motifs, particularly in medicinal chemistry and agrochemical development workflows.

Application

2-(2-Bromo-5-chlorophenyl)acetic acid serves as a versatile building block for pharmaceutical intermediates, enabling efficient C–C and C–heteroatom bond formation. Its ortho-bromine and meta-chlorine substituents provide complementary reactivity in palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates derivatization and purification. The compound exhibits good bench stability and functional group tolerance, making it well-suited for multi-step synthesis workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.7296
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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