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CS-W001157 4
Total: USD 88.00

2,8-Dichloro-4-methylquinoline

  • CAS No. 815583-95-0

  • Cat. No. CS-0063199
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,8-Dichloro-4-methylquinoline|CS-0063199

Structure of 815583-95-0

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General Information

  • CAS No. 815583-95-0
  • Cat. No. CS-0063199
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇Cl₂N
  • Molecular Weight 212.08
  • Synonym(s) Lepidine, 2,8-dichloro- (4CI)
  • SMILES CC1=CC(Cl)=NC2=C(Cl)C=CC=C12

Description

2,8-Dichloro-4-methylquinoline features a rigid quinoline scaffold with electron-withdrawing chlorine atoms at positions 2 and 8, enhancing electrophilicity. The methyl group at C4 introduces steric and electronic modulation, enabling its use in transition metal-catalyzed coupling reactions and as a building block for functionalized heterocycles in medicinal chemistry.

Application

2,8-Dichloro-4-methylquinoline serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized quinoline scaffolds. Its dichloro substitution pattern facilitates subsequent cross-coupling reactions, while the methyl group provides a handle for selective functionalization. The compound exhibits good bench stability and compatibility with standard reaction conditions, making it well-suited for iterative synthesis workflows and heterocycle elaboration in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.85002
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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