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CS-W001157 4
Total: USD 88.00

(2-Amino-4-methylphenyl)methanol

  • CAS No. 81335-87-7

  • Cat. No. CS-0100669
  • Purity≥96%
  • MDL No.MFCD08275453

*For research and further manufacturing use only, not for direct human use.

(2-Amino-4-methylphenyl)methanol|CS-0100669

Structure of 81335-87-7

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General Information

  • CAS No. 81335-87-7
  • Cat. No. CS-0100669
  • Purity ≥96%
  • MDL No. MFCD08275453
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO
  • Molecular Weight None
  • Synonym(s) 4-METHYL-2-NITROBENZYLALCOHOL
  • SMILES OCC1=CC=C(C)C=C1N

Description

This bench-stable arylmethanol features a para-amino group and a methyl substituent, enabling direct incorporation into bioactive scaffolds. The functional handle facilitates coupling reactions under mild conditions, delivering access to diverse heterocyclic systems in medicinal chemistry workflows.

Application

(2-Amino-4-methylphenyl)methanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted anilines and heterocyclic scaffolds. Its ortho-amino and benzylic alcohol functionalities offer complementary reactivity for sequential functionalization, including oxidation to aldehydes, coupling reactions, and cyclization processes. The compound exhibits good bench stability and facilitates straightforward purification, supporting its use in multi-step syntheses and API development workflows.

Synthesis

  • Route1

    References

    • Archiv der Pharmazie (Weinheim, Germany), , p. 583
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 20, # 19 p. 5810 - 5831
  • Route3

    References

    • Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.06952
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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