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CS-W001157 4
Total: USD 88.00

Methyl 4-chloropyrimidine-2-carboxylate

  • CAS No. 811450-17-6

  • Cat. No. CS-0265019
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 4-chloropyrimidine-2-carboxylate|CS-0265019

Structure of 811450-17-6

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Description

Methyl 4-chloropyrimidine-2-carboxylate features a chlorinated pyrimidine core with a methyl ester at the C2 position, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient pyrimidine ring facilitates nucleophilic substitution reactions, while the ester group offers versatility in downstream transformations. This compound serves as a key intermediate in medicinal chemistry for synthesizing kinase inhibitors and antiviral agents.

Application

Methyl 4-chloropyrimidine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds. The chloro group at the 4-position facilitates nucleophilic substitution reactions, while the ester functionality supports selective transformations. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for medicinal chemistry campaigns and process development workflows.

General Information

  • CAS No. 811450-17-6
  • Cat. No. CS-0265019
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O₂
  • Molecular Weight 172.57
  • Synonym(s) 2-Pyrimidinecarboxylic acid, 4-chloro-, methyl ester
  • SMILES O=C(C1=NC=CC(Cl)=N1)OC

Computational Chemistry Data

  • TPSA   52.08
  • LogP   0.9166
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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