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Ethyl 2-bromoimidazo[2,1-b]thiazole-6-carboxylate

  • CAS No. 80353-98-6

  • Cat. No. CS-0151697
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-bromoimidazo[2,1-b]thiazole-6-carboxylate|CS-0151697

Structure of 80353-98-6

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General Information

  • CAS No. 80353-98-6
  • Cat. No. CS-0151697
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂O₂S
  • Molecular Weight 275.12
  • Synonym(s) Ethyl 2-bromoimidazo[2,1-b][1,3]thiazole-6-carboxylate
  • SMILES CCOC(=O)C1=CN2C=C(Br)SC2=N1

Description

Ethyl 2-bromoimidazo[2,1-b]thiazole-6-carboxylate features a brominated imidazo-thiazole core with enhanced reactivity at the C2 position. This electron-deficient heterocycle integrates readily into transition-metal-catalyzed coupling reactions, enabling efficient construction of complex scaffolds in medicinal chemistry and materials synthesis.

Application

Ethyl 2-bromoimidazo[2,1-b]thiazole-6-carboxylate serves as a versatile building block for the synthesis of imidazo[2,1-b]thiazole-based scaffolds. The bromine atom enables palladium-catalyzed cross-coupling reactions, while the ester functionality supports further transformations such as hydrolysis or reduction. This compound exhibits bench stability and facilitates efficient access to medicinally relevant heterocycles through well-established synthetic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   43.6
  • LogP   2.335
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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