Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)-2-pyridinecarboxylic acid

  • CAS No. 80194-69-0

  • Cat. No. CS-W008670
  • Purity≥98%
  • MDL No.MFCD04113632

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)-2-pyridinecarboxylic acid|CS-W008670

Structure of 80194-69-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 80194-69-0
  • Cat. No. CS-W008670
  • Purity ≥98%
  • MDL No. MFCD04113632
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₃NO₂
  • Molecular Weight None
  • Synonym(s) 5-(Trifluoromethyl)pyridine-2-carboxylic acid; 5-Trifluoromethylpicolinic acid; 5-(Trifluoromethyl)picolinic Acid
  • SMILES O=C(C1=NC=C(C(F)(F)F)C=C1)O

Description

5-(Trifluoromethyl)-2-pyridinecarboxylic acid features a strongly electron-deficient pyridine core augmented by a trifluoromethyl group, enhancing its utility in medicinal chemistry and catalysis. This bench-stable carboxylic acid integrates readily into diverse molecular architectures via standard coupling protocols.

Application

5-(Trifluoromethyl)-2-pyridinecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct derivatization via amide, ester, or acyl chloride formation. The molecule exhibits excellent bench stability and compatibility with common purification methods, making it ideal for scalable synthesis and structure-activity studies.

Synthesis

  • Route1

    References

    • US4367336 A1, ;
  • Route2
    • null|null
      124-38-9
    • In-stock
      5-(Trifluoromethyl)-2-bromopyridine|CS-W008678
      50488-42-1
    • ~66%
    • In-stock
      5-(Trifluoromethyl)-2-pyridinecarboxylic acid|CS-W008670
      80194-69-0

    References

    • European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
  • Route3
    • null|null
      124-38-9
    • In-stock
      2-Iodo-5-trifluoromethylpyridine|CS-W004137
      100366-75-4
    • ~47%
    • In-stock
      5-(Trifluoromethyl)-2-pyridinecarboxylic acid|CS-W008670
      80194-69-0

    References

    • European Journal of Organic Chemistry, , # 8 p. 1559 - 1568

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.7986
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 80194-69-0 sigma80194-69-0 manufacturer80194-69-0 price80194-69-0 structure80194-69-0 SDSbuy 80194-69-080194-69-0 supplier80194-69-0 uses80194-69-0 molecular weightprice of 80194-69-080194-69-0 chemical name formula of 80194-69-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label