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Structure of 799557-86-1
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5-Bromo-2-(trifluoromethyl)pyrimidine features a trifluoromethyl group that imparts strong electron-withdrawing character, enhancing reactivity in cross-coupling processes. The bromine substituent enables direct functionalization via palladium-catalyzed reactions. This compound serves as a key building block in medicinal chemistry and agrochemical synthesis.
5-Bromo-2-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions with high efficiency. The bromine at C5 provides a reliable site for Suzuki, Stille, or Negishi coupling, while the trifluoromethyl group enhances metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for multi-step synthesis of complex heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: