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CS-W001157 4
Total: USD 88.00

2,4,6-trifluorobenzoylchloride

  • CAS No. 79538-29-7

  • Cat. No. CS-0695237
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4,6-trifluorobenzoylchloride|CS-0695237

Structure of 79538-29-7

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General Information

  • CAS No. 79538-29-7
  • Cat. No. CS-0695237
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₂ClF₃O
  • Molecular Weight 194.54
  • Synonym(s) None
  • SMILES FC1=CC(F)=C(C(Cl)=O)C(F)=C1

Description

2,4,6-Trifluorobenzoyl chloride delivers a highly electrophilic acyl group for efficient amide bond formation. This bench-stable reagent features three fluorine atoms that enhance reactivity while improving hydrolytic stability compared to unsubstituted analogs. It integrates seamlessly into synthetic workflows requiring selective acylation under mild conditions.

Application

2,4,6-Trifluorobenzoyl chloride serves as a highly reactive acylating agent for the efficient introduction of the electron-deficient trifluoromethylbenzoyl group into diverse substrates. Its enhanced electrophilicity facilitates rapid amide and ester formation under mild conditions, with excellent functional group tolerance and straightforward purification. This reagent is particularly valuable in medicinal chemistry for constructing fluorinated aromatic scaffolds and probing electronic effects in target molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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