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Structure of 79456-28-3
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2-Amino-6-chloro-5-trifluoromethylpyridine features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability, while the amino and chloro substituents enable selective coupling reactions. This pyridine scaffold serves as a key building block in pharmaceutical intermediates, particularly for kinase inhibitors and agrochemicals.
2-Amino-6-chloro-5-trifluoromethylpyridine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via Pd-catalyzed cross-coupling and nucleophilic substitution reactions. The amino group facilitates derivatization, while the chloro and trifluoromethyl substituents offer orthogonal reactivity for late-stage functionalization. Bench-stable and compatible with standard purification protocols, it functions effectively in API synthesis workflows requiring precise regiocontrol and enhanced metabolic stability.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312+H332-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: