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CS-W001157 4
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2-Amino-6-chloro-5-trifluoromethylpyridine

  • CAS No. 79456-28-3

  • Cat. No. CS-W009282
  • Purity≥98%
  • MDL No.MFCD11848573

*For research and further manufacturing use only, not for direct human use.

2-Amino-6-chloro-5-trifluoromethylpyridine|CS-W009282

Structure of 79456-28-3

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General Information

  • CAS No. 79456-28-3
  • Cat. No. CS-W009282
  • Purity ≥98%
  • MDL No. MFCD11848573
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₃N₂
  • Molecular Weight 196.56
  • Synonym(s) 6-Chloro-5-(trifluoromethyl)pyridin-2-amine
  • SMILES NC1=NC(Cl)=C(C(F)(F)F)C=C1

Description

2-Amino-6-chloro-5-trifluoromethylpyridine features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability, while the amino and chloro substituents enable selective coupling reactions. This pyridine scaffold serves as a key building block in pharmaceutical intermediates, particularly for kinase inhibitors and agrochemicals.

Application

2-Amino-6-chloro-5-trifluoromethylpyridine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via Pd-catalyzed cross-coupling and nucleophilic substitution reactions. The amino group facilitates derivatization, while the chloro and trifluoromethyl substituents offer orthogonal reactivity for late-stage functionalization. Bench-stable and compatible with standard purification protocols, it functions effectively in API synthesis workflows requiring precise regiocontrol and enhanced metabolic stability.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.336
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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