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CS-W001157 4
Total: USD 88.00

2-Amino-6-chloro-5-trifluoromethylpyridine

  • CAS No. 79456-28-3

  • Cat. No. CS-W009282
  • Purity≥98%
  • MDL No.MFCD11848573
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Amino-6-chloro-5-trifluoromethylpyridine|CS-W009282

Structure of 79456-28-3

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Description

2-Amino-6-chloro-5-trifluoromethylpyridine features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability, while the amino and chloro substituents enable selective coupling reactions. This pyridine scaffold serves as a key building block in pharmaceutical intermediates, particularly for kinase inhibitors and agrochemicals.

Application

2-Amino-6-chloro-5-trifluoromethylpyridine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via Pd-catalyzed cross-coupling and nucleophilic substitution reactions. The amino group facilitates derivatization, while the chloro and trifluoromethyl substituents offer orthogonal reactivity for late-stage functionalization. Bench-stable and compatible with standard purification protocols, it functions effectively in API synthesis workflows requiring precise regiocontrol and enhanced metabolic stability.

General Information

  • CAS No. 79456-28-3
  • Cat. No. CS-W009282
  • Purity ≥98%
  • MDL No. MFCD11848573
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₃N₂
  • Molecular Weight 196.56
  • Synonym(s) 6-Chloro-5-(trifluoromethyl)pyridin-2-amine
  • SMILES NC1=NC(Cl)=C(C(F)(F)F)C=C1

Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.336
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H302+H312+H332-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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