2-Bromo-5-methylpyridin-4-amine

Name: 2-Bromo-5-methylpyridin-4-amine
Brand: ChemScene
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CAS No. 79055-60-0
Cat. No. CS-0019314
Purity≥96%
MDL No.MFCD11100653

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Bromo-5-methylpyridin-4-amine|CS-0019314

Structure of 79055-60-0

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General Information

CAS No. 79055-60-0
Cat. No. CS-0019314
Purity ≥96%
MDL No. MFCD11100653
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇BrN₂
Molecular Weight 187.04
Synonym(s) 4-Amino-2-bromo-5-methylpyridine
SMILES NC1=CC(Br)=NC=C1C

Description

2-Bromo-5-methylpyridin-4-amine delivers a reactive bromine site and a primary amine positioned ortho to a methyl group on the pyridine ring. This configuration enables efficient cross-coupling transformations and facilitates incorporation into bioactive scaffolds, particularly in kinase inhibitor development. The compound exhibits bench-stable handling characteristics under standard conditions.

Application

2-Bromo-5-methylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine and amine functionalities. The methyl group provides steric and electronic modulation, while the pyridine core offers compatibility with diverse heterocyclic syntheses. Bench-stable and readily purified, it facilitates efficient access to substituted pyridine scaffolds commonly found in pharmaceutical intermediates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.73472
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-Bromo-5-methylpyridin-4-amine

CAS No. 79055-60-0

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