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CS-W001157 4
Total: USD 88.00

7-Chloro-8-methylquinoline

  • CAS No. 78941-93-2

  • Cat. No. CS-0153401
  • Purity≥98%
  • MDL No.MFCD09743893

*For research and further manufacturing use only, not for direct human use.

7-Chloro-8-methylquinoline|CS-0153401

Structure of 78941-93-2

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General Information

  • CAS No. 78941-93-2
  • Cat. No. CS-0153401
  • Purity ≥98%
  • MDL No. MFCD09743893
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈ClN
  • Molecular Weight 177.63
  • Synonym(s) T66 BNJ IG J1 [WLN]
  • SMILES CC1=C2C(=CC=C1Cl)C=CC=N2

Description

7-Chloro-8-methylquinoline is a heterocyclic compound featuring a quinoline core with strategically positioned chlorine and methyl substituents. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and ligand design, offering enhanced stability and tunable reactivity in transition metal-catalyzed transformations.

Application

7-Chloro-8-methylquinoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds. Its chloro and methyl substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and electrophilic functionalization, offering predictable regioselectivity. Bench-stable and readily purified, it functions effectively in late-stage diversification and API intermediate synthesis.

Synthesis

  • Route1
    • In-stock
      5-Chloro-8-methylquinoline|CS-0131202
      78941-95-4
    • ~13%
    • null|null
      611-32-5
    • In-stock
      7-Chloro-8-methylquinoline|CS-0153401
      78941-93-2

    References

    • Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 1093 - 1096 Khimiya Geterotsiklicheskikh Soedinenii, , vol. 19, # 10 p. 1373 - 1376
  • Route2
    • null|null
      611-32-5
    • ~%
    • In-stock
      7-Chloro-8-methylquinoline|CS-0153401
      78941-93-2

    References

    • Chemistry of Heterocyclic Compounds (New York, NY, United States), , p. 1093 - 1096 Khimiya Geterotsiklicheskikh Soedinenii, , vol. 19, # 10 p. 1373 - 1376
  • Route3

    References

    • Journal of the Chemical Society, , p. 437,44

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.19662
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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