(R)-3-Fluoropiperidine hydrochloride

Name: (R)-3-Fluoropiperidine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 787564-37-8
Cat. No. CS-0053327
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-3-Fluoropiperidine hydrochloride|CS-0053327

Structure of 787564-37-8

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General Information

CAS No. 787564-37-8
Cat. No. CS-0053327
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁ClFN
Molecular Weight 139.60
Synonym(s) (3R)-3-fluoropiperidine,hydrochloride
SMILES Cl.F[C@@H]1CCCNC1

Description

(R)-3-Fluoropiperidine hydrochloride is a chiral building block featuring a fluorinated piperidine core with defined stereochemistry. This bench-stable salt delivers a rigid, electron-deficient nitrogen center ideal for integrating into bioactive molecules. Its solubility profile supports use in diverse synthetic transformations, including coupling reactions and late-stage functionalization.

Application

(R)-3-Fluoropiperidine hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated piperidine-containing compounds with defined stereochemistry. Its bench-stable nature and compatibility with common coupling and functionalization reactions facilitate efficient access to bioactive scaffolds. The hydrochloride salt enhances solubility and handling, making it well-suited for modular synthesis workflows in drug discovery.

Synthesis

Route1
- 873221-82-0
- 787564-48-1
- ~30%
- In-stock
  
  787564-37-8
References
- DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1762568 A1, 2007 ; Location in patent: Page/Page column 47 ;
Route2
- 873221-81-9
- ~%
- In-stock
  
  787564-37-8
References
- DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1621537 A1, 2006 ; Location in patent: Page/Page column 59 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP 1.1297
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-3-Fluoropiperidine hydrochloride

CAS No. 787564-37-8

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