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3-Aminothiophene-2-carboxylicacid,sodiumsalt

  • CAS No. 78756-27-1

  • Cat. No. CS-0172935
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Aminothiophene-2-carboxylicacid,sodiumsalt|CS-0172935

Structure of 78756-27-1

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General Information

  • CAS No. 78756-27-1
  • Cat. No. CS-0172935
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NNaO₂S
  • Molecular Weight 166.15
  • Synonym(s) None
  • SMILES [Na].O=C(O)C=1SC=CC1N

Description

3-Aminothiophene-2-carboxylic acid, sodium salt delivers a polar, bench-stable scaffold featuring a conjugated thiophene core with strategically positioned amine and carboxylate groups. This zwitterionic character enhances solubility in aqueous systems while preserving reactivity for coupling applications.

Application

3-Aminothiophene-2-carboxylic acid, sodium salt serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles. Its dual functionality—amine and carboxylate—facilitates efficient coupling reactions and metal-catalyzed transformations. The sodium salt enhances solubility in aqueous and polar organic solvents, simplifying purification and reaction handling. It functions reliably in peptide coupling, Suzuki-Miyaura cross-couplings, and scaffold diversification for pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.6477
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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