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CS-W001157 4
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N-[(2S)-2-Pyrrolidinylmethyl]trifluoromethanesulfonamide

  • CAS No. 782495-18-5

  • Cat. No. CS-0104794
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-[(2S)-2-Pyrrolidinylmethyl]trifluoromethanesulfonamide|CS-0104794

Structure of 782495-18-5

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General Information

  • CAS No. 782495-18-5
  • Cat. No. CS-0104794
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁F₃N₂O₂S
  • Molecular Weight 232.22
  • Synonym(s) N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide
  • SMILES O=S(NC[C@H]1NCCC1)(C(F)(F)F)=O

Description

N-[(2S)-2-Pyrrolidinylmethyl]trifluoromethanesulfonamide features a chiral pyrrolidinylmethyl scaffold paired with a trifluoromethanesulfonyl group, delivering enhanced solubility and stability in polar solvents. This configuration enables efficient incorporation into complex molecular architectures, particularly in medicinal chemistry campaigns requiring robust amine protection or activation strategies.

Application

N-[(2S)-2-Pyrrolidinylmethyl]trifluoromethanesulfonamide serves as a versatile chiral sulfonamide building block, enabling efficient access to enantioselective transformations. Its trifluoromethanesulfonyl group provides high electrophilicity and stability under standard reaction conditions, facilitating coupling with nucleophiles in amide bond formation and catalytic cross-coupling processes. The (2S)-pyrrolidinylmethyl moiety imparts conformational rigidity and favorable solubility, enhancing utility in medicinal chemistry synthesis and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3263
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   58.2
  • LogP   0.1776
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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