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CS-W001157 4
Total: USD 88.00

4-Hydroxyisoleucine

  • CAS No. 781658-23-9

  • Cat. No. CS-W016348
  • Purity≥98%
  • MDL No.MFCD06799350

*For research and further manufacturing use only, not for direct human use.

4-Hydroxyisoleucine|CS-W016348

Structure of 781658-23-9

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General Information

  • CAS No. 781658-23-9
  • Cat. No. CS-W016348
  • Purity ≥98%
  • MDL No. MFCD06799350
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO₃
  • Molecular Weight 147.17
  • Synonym(s) 4-​Hydroxy-​L-​isoleucine
  • SMILES N[C@@H]([C@@H](C)C(O)C)C(O)=O

Description

Dehydroacetic acid is a pyrone derivative, that is typically synthesized by the base-catalyzed dimerization of diketene. It is used as a preservative in pharmaceutical, food and cosmetic products.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Dehydroacetic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical, food and cosmetic formulations by chromatography.

Application

4-Hydroxyisoleucine serves as a valuable non-proteinogenic amino acid scaffold for medicinal chemistry and peptide-based drug discovery. Its hydroxylated side chain enhances hydrogen bonding capacity and metabolic stability, enabling improved solubility and target engagement in bioactive peptide sequences. The molecule exhibits bench stability and compatibility with standard solid-phase peptide synthesis protocols, facilitating efficient incorporation into complex molecular architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.55
  • LogP   -0.5848
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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