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CS-W001157 4
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1-(Bromomethyl)-3,5-dichlorobenzene

  • CAS No. 7778-01-0

  • Cat. No. CS-0037506
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Bromomethyl)-3,5-dichlorobenzene|CS-0037506

Structure of 7778-01-0

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General Information

  • CAS No. 7778-01-0
  • Cat. No. CS-0037506
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrCl₂
  • Molecular Weight 239.93
  • Synonym(s) 1-(Brommethyl)-3,5-dichlorbenzol
  • SMILES C1=C(C=C(C=C1CBr)Cl)Cl

Description

1-(Bromomethyl)-3,5-dichlorobenzene features a reactive bromomethyl group flanked by two electron-withdrawing chloro substituents, enabling efficient coupling reactions in synthetic sequences. This bench-stable aryl halide integrates readily into cross-coupling and nucleophilic substitution processes, offering predictable reactivity for building complex molecular architectures under standard conditions.

Application

1-(Bromomethyl)-3,5-dichlorobenzene serves as a versatile benzylating agent in synthetic organic chemistry, enabling efficient introduction of the 3,5-dichlorobenzyl group into diverse substrates. The bromomethyl functionality reacts readily with nucleophiles under mild conditions, offering high chemoselectivity and compatibility with common functional groups. Its bench-stable nature and ease of purification make it well-suited for multi-step synthesis, including the construction of heterocyclic scaffolds and bioactive intermediates in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • PFIZER LIMITED Patent: WO2006/120544 A1, 2006 ; Location in patent: Page/Page column 50 ;
  • Route2

    References

    • Imperial Chemical Industries PLC Patent: US4705900 A1, 1987 ;
  • Route3

    References

    • Pybus et al. Annals of Applied Biology, 1959 , vol. 47, p. 593,595

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.8883
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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