Lot numbers can be found on the outside label of a product:
1-(2-Bromo-5-methylphenyl)ethanone
-
CAS No. 77344-70-8
- Cat. No. CS-0188433
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 77344-70-8
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 77344-70-8
- Cat. No. CS-0188433
- Purity ≥98%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₉BrO
- Molecular Weight 213.07
- Synonym(s) 1-(2-bromo-5-methylphenyl)ethan-1-one
- SMILES CC1=CC(=C(C=C1)Br)C(=O)C
Description
1-(2-Bromo-5-methylphenyl)ethanone features a brominated aromatic ring fused to an acetyl group, enabling direct functionalization in cross-coupling reactions. The para-methyl substitution enhances electron density at the reaction site, while the bromine serves as a reliable coupling handle. This compound offers high reactivity under standard palladium-catalyzed conditions and maintains stability during storage and handling.
Application
1-(2-Bromo-5-methylphenyl)ethanone serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl architectures. Its bromo group facilitates reliable Suzuki, Stille, and Negishi couplings, while the acetyl functionality offers orthogonal reactivity for further functionalization. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
Synthesis
-
Route1
-
1048108-06-0 -
75-16-1
- ~93%
-
In-stock
77344-70-8
References
-
Thome, Isabelle; Besson, Claire; Kleine, Tillmann; Bolm, Carsten Angewandte Chemie - International Edition, 2013 , vol. 52, # 29 p. 7509 - 7513 Angew. Chem., 2013 , vol. 125, # 29 p. 7657 - 7661,5
-
-
Route2
-
In-stock
5326-34-1 - ~%
-
In-stock
77344-70-8
References
-
Borsche; Scriba Justus Liebigs Annalen der Chemie, 1939 , vol. 541, p. 283,290
-
-
Route3
-
In-stock
53078-85-6 - ~%
-
In-stock
77344-70-8
References
-
Borsche; Scriba Justus Liebigs Annalen der Chemie, 1939 , vol. 541, p. 283,290
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319
|
|
|
Precautionary Statements : P261-P302+P352
|
|
Quality Control
Computational Chemistry Data
- TPSA 17.07
- LogP 2.96012
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 1-(2-Bromo-5-methylphenyl)ethanone sigma1-(2-Bromo-5-methylphenyl)ethanone manufacturer1-(2-Bromo-5-methylphenyl)ethanone price1-(2-Bromo-5-methylphenyl)ethanone structure1-(2-Bromo-5-methylphenyl)ethanone SDSbuy 1-(2-Bromo-5-methylphenyl)ethanone1-(2-Bromo-5-methylphenyl)ethanone supplier1-(2-Bromo-5-methylphenyl)ethanone uses1-(2-Bromo-5-methylphenyl)ethanone molecular weightprice of 1-(2-Bromo-5-methylphenyl)ethanone1-(2-Bromo-5-methylphenyl)ethanone chemical name formula of 1-(2-Bromo-5-methylphenyl)ethanone