Lot numbers can be found on the outside label of a product:
Boc-Piperazine-OH
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CAS No. 77279-24-4
- Cat. No. CS-W009135
- Purity≥98%
- MDL No.MFCD00728947
*For research and further manufacturing use only, not for direct human use.
Structure of 77279-24-4
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General Information
- CAS No. 77279-24-4
- Cat. No. CS-W009135
- Purity ≥98%
- MDL No. MFCD00728947
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₂₂N₂O₃
- Molecular Weight 230.30
- Synonym(s) None
- SMILES OCCN1CCN(C(OC(C)(C)C)=O)CC1
Description
Boc-Piperazine-OH features a protected piperazine core with a terminal hydroxyl group, enabling direct incorporation into peptide and small-molecule scaffolds. The Boc group ensures stability during synthesis, while the OH moiety offers a handle for further derivatization under standard conditions. This compound serves as a key building block in medicinal chemistry campaigns targeting bioactive heterocycles.
Application
Boc-Piperazine-OH serves as a versatile building block in medicinal chemistry, enabling the efficient introduction of piperazine scaffolds into target molecules. The Boc group provides stable protection under standard conditions, facilitating orthogonal deprotection during multi-step synthesis. It exhibits excellent functional group tolerance and reacts reliably in amide coupling and nucleophilic substitution reactions, making it ideal for constructing bioactive compounds and API intermediates with predictable reactivity and ease of purification.
Synthesis
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Route1
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103-76-4 -
In-stock
24424-99-5 - ~99%
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In-stock
77279-24-4
References
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BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG Patent: WO2006/107923 A1, 2006 ; Location in patent: Page/Page column 66 ;
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Route2
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103-76-4
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In-stock
34619-03-9 - ~86%
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In-stock
77279-24-4
References
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Hoffmann-La Roche Inc.; Hermann, Johannes Cornelius; Kuglstatter, Andreas; Lucas, Matthew C.; Padilla, Fernando; Wanner, Jutta; Zhang, Xiaohu Patent: US2013/109661 A1, 2013 ; Location in patent: Paragraph 0620-0621 ;
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Route3
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540-51-2 -
57260-71-6 - ~87%
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In-stock
77279-24-4
References
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Hill, Pamela J.; Abibi, Ayome; Albert, Robert; Andrews, Beth; Gagnon, Moriah M.; Gao, Ning; Grebe, Tyler; Hajec, Laurel I.; Huang, Jian; Livchak, Stephania; Lahiri, Sushmita D.; McKinney, David C.; Thresher, Jason; Wang, Hongming; Olivier, Nelson; Buurman, Ed T. Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7278 - 7288
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS06,GHS09
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H410
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Precautionary Statements : P264-P270-P273-P330-P391-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 53.01
- LogP 0.5314
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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