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CS-W001157 4
Total: USD 88.00

N,N-Diethylbenzylamine

  • CAS No. 772-54-3

  • Cat. No. CS-0015347
  • Purity≥97%
  • MDL No.MFCD00026731

*For research and further manufacturing use only, not for direct human use.

N,N-Diethylbenzylamine|CS-0015347

Structure of 772-54-3

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General Information

  • CAS No. 772-54-3
  • Cat. No. CS-0015347
  • Purity ≥97%
  • MDL No. MFCD00026731
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇N
  • Molecular Weight 163.26
  • Synonym(s) N-benzyl-N-ethylethanamine
  • SMILES CCN(CC)CC1=CC=CC=C1

Description

N,N-Diethylbenzylamine serves as a versatile tertiary amine catalyst in organic synthesis, offering enhanced nucleophilicity and solubility in both polar and nonpolar media. This bench-stable reagent facilitates efficient imine formation, Mannich reactions, and phase-transfer catalysis under mild conditions. Its electron-rich nitrogen center enables rapid proton abstraction and stabilization of reactive intermediates.

Application

N,N-Diethylbenzylamine serves as a versatile tertiary amine catalyst and ligand in transition metal-catalyzed reactions, enabling efficient C–C and C–heteroatom bond formations. Its benzylic nitrogen imparts enhanced nucleophilicity and steric profile, facilitating reactions under mild conditions. The molecule exhibits good bench stability and ease of purification, making it well-suited for scalable synthesis and process chemistry applications.

Synthesis

  • Route1

    References

    • Kuwano, Ryoichi; Takahashi, Masatoshi; Ito, Yoshihiko Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1017 - 1020
  • Route2
    • null|null
      100-52-7
    • null|null
      109-89-7
    • ~92%
    • In-stock
      N,N-Diethylbenzylamine|CS-0015347
      772-54-3

    References

    • Azizi; Amiri, A. R. Khajeh; Ghafuri; Saidi; Bolourtchian Journal of the Iranian Chemical Society, 2010 , vol. 7, # 2 p. 428 - 431
  • Route3
    • null|null
      100-39-0
    • null|null
      109-89-7
    • ~81%
    • In-stock
      N,N-Diethylbenzylamine|CS-0015347
      772-54-3

    References

    • Sperotto, Elena; van Klink, Gerard P.M.; de Vries, Johannes G.; van Koten, Gerard Tetrahedron, 2010 , vol. 66, # 19 p. 3478 - 3484

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   2.5284
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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