(2,6-Difluoro-4-methoxyphenyl)methanamine

Name: (2,6-Difluoro-4-methoxyphenyl)methanamine
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CAS No. 771573-20-7
Cat. No. CS-0314559
Purity≥97%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(2,6-Difluoro-4-methoxyphenyl)methanamine|CS-0314559

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General Information

CAS No. 771573-20-7
Cat. No. CS-0314559
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₉F₂NO
Molecular Weight 173.16
Synonym(s) 2,6-Difluoro-4-methoxybenzylamine
SMILES COC1=CC(=C(CN)C(=C1)F)F

Description

This difluoromethoxyphenylamine derivative features a methoxy group at the 4-position and fluorine atoms at the 2,6-positions, enhancing electron-withdrawal and metabolic stability. The primary amine enables direct coupling in pharmaceutical synthesis, while the aryl framework supports integration into bioactive scaffolds requiring lipophilic character and targeted electronic tuning.

Application

(2,6-Difluoro-4-methoxyphenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient aromatic core enhances metabolic stability, while the primary amine facilitates facile derivatization via amidation, alkylation, or reductive amination. Bench-stable and compatible with standard purification protocols, it functions effectively in coupling reactions and scaffold diversification for drug discovery campaigns.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P304+P340-P330-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 1.4321
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(2,6-Difluoro-4-methoxyphenyl)methanamine

CAS No. 771573-20-7

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