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CS-W001157 4
Total: USD 88.00

Fmoc-N-Me-Phe-OH

  • CAS No. 77128-73-5

  • Cat. No. CS-W011702
  • Purity≥97%
  • MDL No.MFCD00151938

*For research and further manufacturing use only, not for direct human use.

Fmoc-N-Me-Phe-OH|CS-W011702

Structure of 77128-73-5

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General Information

  • CAS No. 77128-73-5
  • Cat. No. CS-W011702
  • Purity ≥97%
  • MDL No. MFCD00151938
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₃NO₄
  • Molecular Weight 401.46
  • Synonym(s) None
  • SMILES O=C(O)[C@H](CC1=CC=CC=C1)N(C(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)C

Description

Fmoc-N-Me-Phe-OH is a protected phenylalanine derivative featuring a fluorenylmethoxycarbonyl group and a methylated amide nitrogen. This configuration enhances stability and reduces susceptibility to racemization during peptide synthesis. The N-methyl substitution improves membrane permeability and metabolic resistance, making it valuable for developing bioactive peptides with enhanced pharmacokinetic profiles.

Synthesis

  • Route1
    • (9H-fluoren-9-yl)methyl (S)-4-benzyl-5-oxooxazolidine-3-carboxylate|CS-0466557
      84000-03-3
    • ~91%
    • In-stock
      Fmoc-N-Me-Phe-OH|CS-W011702
      77128-73-5

    References

    • Buba, Annette E.; Koch, Stefan; Kunz, Horst; Loewe, Holger European Journal of Organic Chemistry, 2013 , # 21 p. 4509 - 4513
  • Route2
    • In-stock
      (S)-2-(Methylamino)-3-phenylpropanoic acid|CS-W005388
      2566-30-5
    • null|null
      28920-43-6
    • ~92%
    • In-stock
      Fmoc-N-Me-Phe-OH|CS-W011702
      77128-73-5

    References

    • Bain, J. D.; Wacker, Dean A.; Kuo, Eric E.; Lyttle, Matthew H.; Chamberlin, A. Richard Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4615 - 4625
  • Route3
    • null|null
      1208119-54-3
    • null|null
      28920-43-6
    • ~70%
    • In-stock
      Fmoc-N-Me-Phe-OH|CS-W011702
      77128-73-5

    References

    • Leggio, Antonella; Belsito, Emilia Lucia; De Marco, Rosaria; Liguori, Angelo; Perri, Francesca; Viscomi, Maria Caterina Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1386 - 1392

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   4.5632
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   6

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