Lot numbers can be found on the outside label of a product:
(R)-tert-Butyl (1-oxo-3-phenylpropan-2-yl)carbamate
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CAS No. 77119-85-8
- Cat. No. CS-0186140
- Purity≥95%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 77119-85-8
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General Information
- CAS No. 77119-85-8
- Cat. No. CS-0186140
- Purity ≥95%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₄H₁₉NO₃
- Molecular Weight 249.31
- Synonym(s) (R)-(+)-2-(tert-Butoxycarbonylamino)-3-phenylpropanal
- SMILES CC(C)(OC(N[C@@H](C=O)CC1=CC=CC=C1)=O)C
Description
(R)-tert-Butyl (1-oxo-3-phenylpropan-2-yl)carbamate is a chiral building block featuring a stereodefined quaternary center, enabling precise asymmetric synthesis. The carbamate group provides stable protection for amine functionalities, while the phenyl-substituted ketone moiety offers a handle for further functionalization. This scaffold integrates readily into complex molecular architectures under standard conditions.
Application
(R)-tert-Butyl (1-oxo-3-phenylpropan-2-yl)carbamate serves as a chiral building block for synthesizing biologically active molecules, enabling efficient access to enantiomerically pure α-aryl-β-keto amine motifs. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate straightforward transformations in medicinal chemistry workflows. The carbamate protecting group allows for selective deprotection and further derivatization, supporting scalable synthesis of complex heterocyclic scaffolds and API intermediates.
Synthesis
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Route1
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19901-50-9 - ~89%
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In-stock
77119-85-8
References
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PHENEX PHARMACEUTICALS AG; KINZEL, Olaf; STEENECK, Christoph; KLEYMANN, Gerald; ALBERS, Michael; HOFFMANN, Thomas; KREMOSER, Claus; PEROVIC-OTTSTADT, Sanja; SCHLUeTER, Thomas Patent: WO2011/107248 A1, 2011 ; Location in patent: Page/Page column 68; 69 ; WO 2011/107248 A1
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Route2
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In-stock
106454-69-7 - ~97%
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In-stock
77119-85-8
References
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MENARINI RICERCHE S.P.A. Patent: WO2004/94412 A1, 2004 ; Location in patent: Page 10 ;
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Route3
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115186-33-9 - ~71%
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In-stock
77119-85-8
References
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Fukumizu, Atsuko; Tsuda, Yuko Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 8 p. 1141 - 1144
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.4
- LogP 2.3213
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 4
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Key Words
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