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CS-W001157 4
Total: USD 88.00

Phenyl phosphorodichloridate

  • CAS No. 770-12-7

  • Cat. No. CS-0016064
  • Purity≥97%
  • MDL No.MFCD00002067

*For research and further manufacturing use only, not for direct human use.

Phenyl phosphorodichloridate|CS-0016064

Structure of 770-12-7

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General Information

  • CAS No. 770-12-7
  • Cat. No. CS-0016064
  • Purity ≥97%
  • MDL No. MFCD00002067
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂O₂P
  • Molecular Weight 210.98
  • Synonym(s) Phenylphosphoric Acid Dichloride
  • SMILES O=P(Cl)(Cl)OC1=CC=CC=C1

Description

Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry.

Synthesis

  • Route1
    • null|null
      108-95-2
    • ~95%
    • In-stock
      Phenyl phosphorodichloridate|CS-0016064
      770-12-7

    References

    • CHIMERIX, INC.; ALMOND, Merrick; LANIER, Ernest, Randall; MUSSO, David, Lee; WARE, Roy Patent: WO2010/135520 A1, 2010 ; Location in patent: Page/Page column 88 ;
  • Route2
    • null|null
      3426-89-9
    • ~99%
    • In-stock
      Phenyl phosphorodichloridate|CS-0016064
      770-12-7

    References

    • Caminade, Anne-Marie; El Khatib, Fayez; Baceiredo, Antoine; Koenig, Max Phosphorus and Sulfur and the Related Elements, 1987 , vol. 29, p. 365 - 368
  • Route3
    • null|null
      139-02-6
    • ~89%
    • In-stock
      Phenyl phosphorodichloridate|CS-0016064
      770-12-7

    References

    • Rathore, M.; Kabra, A.; Rani, P.; Narang, C. K.; Mathur, N. K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 10 p. 1066 - 1067

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   3.6511
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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