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Structure of 77-57-6
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1-Phenylcyclopentane-1-carbonitrile features a rigid cyclopentane core bearing a phenyl group and a nitrile substituent at the same carbon, delivering high structural stability. This configuration imparts strong electron-withdrawing character through the nitrile, enabling use in synthetic routes requiring defined steric and electronic control. The compound exhibits excellent bench-stability and solubility in common organic solvents, facilitating straightforward integration into multistep synthesis workflows.
1-Phenylcyclopentane-1-carbonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds through functional group interconversion. The nitrile moiety offers high stability and compatibility with diverse reaction conditions, facilitating subsequent transformations such as amidation, reduction to primary amine, or hydrolysis to carboxylic acid. Its rigid, lipophilic cyclopentane framework provides structural constraint beneficial for target engagement, while the pendant phenyl ring supports π–π interactions in binding sites. Ideal for iterative synthesis workflows due to predictable reactivity and ease of purification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: