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CS-W001157 4
Total: USD 88.00

5-Methoxyoxindole

  • CAS No. 7699-18-5

  • Cat. No. CS-W004815
  • Purity≥96%
  • MDL No.MFCD01860251

*For research and further manufacturing use only, not for direct human use.

5-Methoxyoxindole|CS-W004815

Structure of 7699-18-5

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General Information

  • CAS No. 7699-18-5
  • Cat. No. CS-W004815
  • Purity ≥96%
  • MDL No. MFCD01860251
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO₂
  • Molecular Weight 163.17
  • Synonym(s) 5-methoxyindolin-2-one
  • SMILES COC2=CC=C1NC(CC1=C2)=O

Description

5-Methoxyoxindole delivers a robust oxindole scaffold with a methoxy group at the 5-position, enhancing electron density and solubility in polar solvents. This bench-stable derivative serves as a key intermediate in medicinal chemistry, particularly for kinase inhibitors and CNS-targeted compounds.

Application

5-Methoxyoxindole serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient access to oxindole-based scaffolds. The methoxy group enhances solubility and modulates electronic properties, supporting downstream derivatization in drug discovery programs.

Synthesis

  • Route1
    • null|null
      742067-26-1
    • ~60%
    • In-stock
      5-Methoxyoxindole|CS-W004815
      7699-18-5

    References

    • NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2004/76455 A1, 2004 ; Location in patent: Page 25 ; WO 2004/076455 A1
  • Route2
    • null|null
      27387-22-0
    • ~72%
    • In-stock
      5-Methoxyoxindole|CS-W004815
      7699-18-5

    References

    • Jhan, Yu-Huei; Kang, Ting-Wei; Hsieh, Jen-Chieh Tetrahedron Letters, 2013 , vol. 54, # 9 p. 1155 - 1159
  • Route3

    References

    • Crestini; Saladino Synthetic Communications, 1994 , vol. 24, # 20 p. 2835 - 2841

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.1898
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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