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Total: USD 88.00

8-Hydroxy-3,4-dihydronaphthalen-1(2H)-one

  • CAS No. 7695-47-8

  • Cat. No. CS-0113178
  • Molecule weight162.19
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Hydroxy-3,4-dihydronaphthalen-1(2H)-one|CS-0113178

Structure of 7695-47-8

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General Information

  • CAS No. 7695-47-8
  • Cat. No. CS-0113178
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₂
  • Molecular Weight 162.19
  • Synonym(s) PENTYL 3-OXO-2-PENTYLOCTANOATE
  • SMILES O=C1CCCC2=C1C(O)=CC=C2

Description

8-Hydroxy-3,4-dihydronaphthalen-1(2H)-one features a fused tricyclic core with a phenolic hydroxyl and carbonyl group in close spatial proximity. This arrangement enables intramolecular hydrogen bonding, enhancing stability and influencing reactivity in synthetic transformations. The molecule exhibits moderate solubility in polar organic solvents and displays bench-stable behavior under standard conditions, making it suitable for use in complex synthesis workflows.

Application

8-Hydroxy-3,4-dihydronaphthalen-1(2H)-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted naphthalene derivatives. Its ortho-hydroxy ketone functionality facilitates intramolecular cyclizations and acts as a key scaffold for heterocyclic systems. The compound exhibits good bench stability and compatibility with common functional groups, facilitating straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • Miyashita, Kazuyuki; Sakai, Takayuki; Imanishi, Takeshi Organic letters, 2003 , vol. 5, # 15 p. 2683 - 2686
  • Route2

    References

    • Hochstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 5455,5474
  • Route3

    References

    • Kozelj, Matjaz; Petric, Andrej Synlett, 2007 , # 11 p. 1699 - 1702

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9112
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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