Pyrazolo[1,5-a]pyridin-2-ylmethanol

Name: Pyrazolo[1,5-a]pyridin-2-ylmethanol
Brand: ChemScene
Availability: InStock
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CAS No. 76943-47-0
Cat. No. CS-0270744
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Pyrazolo[1,5-a]pyridin-2-ylmethanol|CS-0270744

Structure of 76943-47-0

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General Information

CAS No. 76943-47-0
Cat. No. CS-0270744
Purity ≥96%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈N₂O
Molecular Weight 148.16
Synonym(s) 2-hydroxymethylpyrazolo[1,5-a]pyridine
SMILES C1=CC2=CC(=NN2C=C1)CO

Description

Pyrazolo[1,5-a]pyridin-2-ylmethanol integrates a rigid heterocyclic core with a reactive benzylic alcohol, enabling direct functionalization in medicinal chemistry. This bench-stable scaffold supports efficient derivatization for kinase inhibitors and targeted therapeutics.

Application

Pyrazolo[1,5-a]pyridin-2-ylmethanol serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its benzylic alcohol functionality facilitates direct functionalization—such as oxidation to carboxylic acids or conversion to esters and amides—while maintaining compatibility with common protecting group strategies. The rigid, electron-deficient core supports diverse coupling reactions and offers favorable physicochemical properties for drug discovery applications.

Synthesis

Route1
- In-stock
  
  63237-88-7
- ~75%
- In-stock
  
  76943-47-0
References
- LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, José Luis; CUBERES ALTISENT, Mª Rosa Patent: WO2013/124341 A1, 2013 ; Location in patent: Page/Page column 35-36 ;
Route2
- 76943-44-7
- ~73%
- In-stock
  
  76943-47-0
References
- Tsuchiya, Takashi; Sashida, Haruki Journal of the Chemical Society, Chemical Communications, 1980 , # 23 p. 1109 - 1110

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 37.53
LogP 0.8266
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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Pyrazolo[1,5-a]pyridin-2-ylmethanol

CAS No. 76943-47-0

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