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Structure of 769159-85-5
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4-Cyclopropyl-1-fluoro-2-nitrobenzene features a fluorine atom at the ortho position relative to a nitro group, creating a strongly electron-deficient aromatic core. The cyclopropyl substituent imparts steric and electronic modulation, enhancing metabolic stability. This compound serves as a key building block in medicinal chemistry for constructing bioactive scaffolds requiring precise electronic tuning and resistance to degradation under physiological conditions.
4-Cyclopropyl-1-fluoro-2-nitrobenzene serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling and nucleophilic aromatic substitution. The ortho-nitro and fluoro groups provide complementary reactivity for sequential derivatization, while the cyclopropyl substituent offers enhanced metabolic stability and tunable lipophilicity. Bench-stable and compatible with standard purification protocols, it facilitates efficient access to substituted heterocycles and bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: