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CS-W001157 4
Total: USD 88.00

1,4-Bis(diphenylphosphino)butane

  • CAS No. 7688-25-7

  • Cat. No. CS-W007569
  • Molecule weight426.47
  • Purity≥97%
  • MDL No.MFCD00003051

*For research and further manufacturing use only, not for direct human use.

1,4-Bis(diphenylphosphino)butane|CS-W007569

Structure of 7688-25-7

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General Information

  • CAS No. 7688-25-7
  • Cat. No. CS-W007569
  • Purity ≥97%
  • MDL No. MFCD00003051
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₈H₂₈P₂
  • Molecular Weight 426.47
  • Synonym(s) None
  • SMILES C4=C(P(C1=CC=CC=C1)CCCCP(C2=CC=CC=C2)C3=CC=CC=C3)C=CC=C4

Description

Employed as a ligand in Pd(0)-catalyzed acylcyanation of arylacetylenes and deprotection of allyloxycarbamates.

Application

1,4-Bis(diphenylphosphino)butane serves as a versatile bidentate phosphine ligand in transition metal catalysis, particularly in palladium- and nickel-catalyzed cross-coupling reactions. Its rigid yet flexible backbone enhances catalyst stability and turnover, enabling efficient C–C and C–heteroatom bond formations under mild conditions. The ligand exhibits excellent functional group tolerance and facilitates easy purification of reaction mixtures, making it well-suited for iterative synthesis and process-scale applications.

Synthesis

  • Route1
    • Butane-1,4-diylbis(diphenylphosphineoxide)|CS-0639551
      4151-27-3
    • ~97%
    • In-stock
      1,4-Bis(diphenylphosphino)butane|CS-W007569
      7688-25-7

    References

    • Synlett, , # 10 p. 1545 - 1548
  • Route2
    • null|null
      110-52-1
    • null|null
      829-85-6
    • ~86%
    • In-stock
      1,4-Bis(diphenylphosphino)butane|CS-W007569
      7688-25-7

    References

    • Tetrahedron Letters, , vol. 44, # 46 p. 8373 - 7377
  • Route3
    • null|null
      110-52-1
    • null|null
      1079-66-9
    • ~85%
    • null|null
      1101-41-3
    • In-stock
      1,4-Bis(diphenylphosphino)butane|CS-W007569
      7688-25-7

    References

    • Tetrahedron Letters, , vol. 28, # 17 p. 1885 - 1886

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   6.0324
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   9

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