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CS-W001157 4
Total: USD 88.00

3-Bromo-5-(trifluoromethyl)pyridin-2-ol

  • CAS No. 76041-73-1

  • Cat. No. CS-W006257
  • Purity≥98%
  • MDL No.MFCD02691223

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-(trifluoromethyl)pyridin-2-ol|CS-W006257

Structure of 76041-73-1

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General Information

  • CAS No. 76041-73-1
  • Cat. No. CS-W006257
  • Purity ≥98%
  • MDL No. MFCD02691223
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃NO
  • Molecular Weight 241.99
  • Synonym(s) 3-bromo-5-(trifluoromethyl)pyridin-2(1H)-one
  • SMILES O=C1C(Br)=CC(C(F)(F)F)=CN1

Description

3-Decyn-1-ol may be used in the following studies, as a starting material in the synthesis of 3?-deoxyribolactones, as a starting material in the synthesis of (Z)-3-decen-1-ol by hydrogenation over P-2 nickel and as a reagent in the synthesis of methyl 9-decynoate.

Application

3-Bromo-5-(trifluoromethyl)pyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromo group and stabilizing trifluoromethyl substituent. The phenolic hydroxyl group offers direct functionalization potential and enhances solubility. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds and drug candidates.

Synthesis

  • Route1

    References

    • Xue, Chu-Biao; Zheng, Changsheng; Cao, Ganfeng; Feng, Hao; Xia, Michael; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W. Patent: US2005/267146 A1, 2005 ; Location in patent: Page/Page column 22-23 ; US 20050267146 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   2.1562
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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