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CS-W001157 4
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4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

  • CAS No. 758699-74-0

  • Cat. No. CS-W018707
  • Purity≥97%
  • MDL No.MFCD07367561

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|CS-W018707

Structure of 758699-74-0

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General Information

  • CAS No. 758699-74-0
  • Cat. No. CS-W018707
  • Purity ≥97%
  • MDL No. MFCD07367561
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈BNO₃
  • Molecular Weight 235.09
  • Synonym(s) 4-METHOXYPYRIDINE-3-BORONIC ACID PINACOL ESTER
  • SMILES CC1(C)C(C)(C)OB(C2=C(OC)C=CN=C2)O1

Description

4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine features a boronate ester group paired with an electron-rich pyridine core, enabling efficient Suzuki-Miyaura coupling under mild conditions. This bench-stable reagent integrates seamlessly into complex molecule assembly, offering high functional group tolerance and predictable regiochemistry in cross-coupling workflows.

Application

4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The pinacol ester group ensures excellent bench stability and low toxicity, while the pyridine core enables efficient coupling with aryl and heteroaryl halides. Functional group tolerance and straightforward purification make it ideal for constructing complex pharmaceutical scaffolds and conjugated materials in industrial R&D settings.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.58
  • LogP   1.3894
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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