2-Methoxypyrimidine-4-carboxylic acid

Name: 2-Methoxypyrimidine-4-carboxylic acid
Brand: ChemScene
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CAS No. 75825-60-4
Cat. No. CS-0150215
Purity≥95%
MDL No.MFCD16657305

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Methoxypyrimidine-4-carboxylic acid|CS-0150215

Structure of 75825-60-4

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General Information

CAS No. 75825-60-4
Cat. No. CS-0150215
Purity ≥95%
MDL No. MFCD16657305
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆N₂O₃
Molecular Weight 154.12
Synonym(s) None
SMILES COC1=NC=CC(=N1)C(=O)O

Description

2-Methoxypyrimidine-4-carboxylic acid features a pyrimidine core functionalized with a methoxy group at the 2-position and a carboxylic acid at the 4-position. This combination imparts enhanced solubility and reactivity, enabling efficient coupling in synthetic transformations. The molecule exhibits favorable stability under standard conditions and serves as a key building block in medicinal chemistry and agrochemical development.

Application

2-Methoxypyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its carboxylic acid functionality facilitates amide coupling and esterification under standard conditions, while the methoxy group provides orthogonal reactivity for further functionalization. The molecule exhibits good bench stability and is readily purified by recrystallization, making it well-suited for use in multi-step syntheses of API candidates and heterocyclic intermediates.

Synthesis

Route1
- 75825-59-1
- ~62%
- In-stock
  
  75825-60-4
References
- Warczykowska, Iwona; Wojciechowski, Jan Polish Journal of Chemistry, 1980 , vol. 54, # 2 p. 335 - 340
Route2
- In-stock
  
  75833-38-4
- ~%
- In-stock
  
  75825-60-4
References
- Warczykowska, Iwona; Wojciechowski, Jan Polish Journal of Chemistry, 1980 , vol. 54, # 2 p. 335 - 340

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 72.31
LogP 0.1834
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Methoxypyrimidine-4-carboxylic acid

CAS No. 75825-60-4

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