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CS-W001157 4
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3-(Pyridin-2-yl)pyrazole

  • CAS No. 75415-03-1

  • Cat. No. CS-D1332
  • Purity≥97%
  • MDL No.MFCD00115151

*For research and further manufacturing use only, not for direct human use.

3-(Pyridin-2-yl)pyrazole|CS-D1332

Structure of 75415-03-1

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General Information

  • CAS No. 75415-03-1
  • Cat. No. CS-D1332
  • Purity ≥97%
  • MDL No. MFCD00115151
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃
  • Molecular Weight 145.17
  • Synonym(s) None
  • SMILES N1=CC=CC=C1C2=NNC=C2

Description

3-(Pyridin-2-yl)pyrazole features a fused heterocyclic architecture combining pyridine and pyrazole rings, enabling strong π-stacking and metal coordination. This scaffold integrates into ligand design for catalysis and bioactive molecule development, offering enhanced solubility and stability under standard conditions.

Application

3-(Pyridin-2-yl)pyrazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to biologically active scaffolds. Its pyrazole core exhibits strong hydrogen-bonding capacity and π-stacking potential, while the pyridin-2-yl group enhances solubility and facilitates metal coordination. The compound demonstrates robust bench stability, tolerates a range of functional groups, and participates reliably in Pd-catalyzed cross-coupling reactions, making it well-suited for modular synthesis of drug-like molecules.

Synthesis

  • Route1
    • null|null
      75415-00-8
    • ~99%
    • In-stock
      3-(Pyridin-2-yl)pyrazole|CS-D1332
      75415-03-1

    References

    • SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTD.; Si Chuan University; LUO, Youfu; WANG, Zhenling; WEI, Yuquan; GENG, Funeng Patent: EP2738169 A1, 2014 ; Location in patent: Paragraph 0105; 0106; 0107 ;
  • Route2

    References

    • BIOGEN IDEC MA INC. Patent: WO2004/72033 A2, 2004 ; Location in patent: Page 35 ; WO 2004/072033 A2
  • Route3
    • 1-(Pyridin-2-yl)ethanone  Imatinib Impurity|CS-0167014
      1122-62-9
    • ~%
    • In-stock
      3-(Pyridin-2-yl)pyrazole|CS-D1332
      75415-03-1

    References

    • Synthesis, , # 1 p. 55 - 62

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.4717
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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